Qsymia long term side effects - Adults Adverse reactions occurring at greater than or equal to 5% and at least 1.5 times placebo in adults include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth. Adverse reactions reported in greater than or equal to 2% of QSYMIA-treated adults and more frequently than in the placebo group are shown in Table 3. Table 3.

 
Common side effects include tingling, dizziness, trouble sleeping, and constipation. Serious side effects may include suicide, abuse. Use is not recommended during pregnancy. Phentermine is a stimulant and appetite suppressant. Topiramate is an anticonvulsant that has weight loss side effects.. Bficsymc

Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use.Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use.After stopping phentermine, some people experience feelings of weariness and fatigue due to the sudden lack of chemical stimulation. If you are tired after stopping phentermine, take care to: Get enough sleep. Fuel your body with healthy foods: avoid high-fat, high-carb, and high-sugar goods that may worsen fatigue. Stay lightly active.Phentermine has the advantage of low cost and many years of clinical experience, but its long-term use is considered off-label, long-term effects on CVD outcomes are unknown, and most use has been a few months or less. 41 There are even fewer data for long-term safety and efficacy of the other noradrenergic agents. Orlistat has a reasonably ...Mar 13, 2023 · weight loss. impaired taste (changes in how things taste) trouble with memory. More common side effects in people taking Topamax for epilepsy include: tingling in the legs and arms. loss of ... Feb 14, 2023 · Summary. Commonly reported side effects of orlistat include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Qsymia side effects can include trouble sleeping if taken in the evening and potential seizures if you stop the medication abruptly. Other side effects can include dizziness, drowsiness, dry mouth, tiredness, tingling of the hands/feet, constipation, and metallic tastes. Some of the more serious side effects can include temporary difficulty ...What Is Wegovy? Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e ...trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Serious eye problems which include: Other side effects. Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use.or short-term obesity treatment in conjunction with lifestyle modifications, but is commonly used chronically. Topiramate, approved for treating epilepsy and preventing migraines, also induces weight loss. A single-dose combination of low-dose phentermine and topiramate extended-release was recently approved by the United States Food and Drug Administration as an adjunct to lifestyle ...Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Side effects include: Oily spotting ...Objective: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. Methods: Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months).weight loss. impaired taste (changes in how things taste) trouble with memory. More common side effects in people taking Topamax for epilepsy include: tingling in the legs and arms. loss of ...PHEN is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. It has been available in the US since 1959 for short-term (generally regarded as 12 weeks) treatment of obesity in dose range of 15 mg/day to 37.5 mg/day.Places you in a long-term behavioral changing plan; The Cons. Serious side-effects; Some people didn’t notice that many benefits; The results they claim are underwhelming; Qsymia Conclusion. Qsymia is an example of a prescription drug for weight loss that might do more harm than good.Qsymia side effects can include trouble sleeping if taken in the evening and potential seizures if you stop the medication abruptly. Other side effects can include dizziness, drowsiness, dry mouth, tiredness, tingling of the hands/feet, constipation, and metallic tastes. Some of the more serious side effects can include temporary difficulty ...Qsymia (phentermine and topiramate) is a weight loss medication used to help people who are overweight or obese, along with diet and exercise, to lose weight and keep the weight off. Common side effects of Qsymia include sensations of pricking, burning, tingling, or numbness of the skin; dizziness, blurred vision, fatigue, indigestion, urinary tract infections (UTIs), headache, nausea, back ...The highest dose of Qsymia contains only 15mg of Phentermine, but the average dose of Phentermine (for weight loss when used by itself) is 37.5mg. While it may be nice to have a combination medication, it may actually be better to prescribe both medications individually so you have more control over the dosages of each medication.This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen. If you are taking any of these drugs: Linezolid or methylene blue. If you are pregnant or may be pregnant. Do not take this drug if you are pregnant. If you are breast-feeding.Phentermine has the advantage of low cost and many years of clinical experience, but its long-term use is considered off-label, long-term effects on CVD outcomes are unknown, and most use has been a few months or less. 41 There are even fewer data for long-term safety and efficacy of the other noradrenergic agents. Orlistat has a reasonably ...Dec. 4, 2019 — A new study finds the only reliable way to measure exposure to radon gas is with a long-term testing kit, 90 or more days. Researchers placed two test kits, a short term (five-day ...Feb 3, 2023 · Phentermine alone is designed for short-term use only, as there are few long-term studies on its safety. One study observed that people experienced no significant side effects when they took ... Mar 29, 2022 · Tardive dyskinesia is a movement disorder that is a side effect of medications, especially first-generation antipsychotics. Less common causes are second-generation antipsychotics, antidepressants, mood stabilizers, antiepileptic drugs, movement disorder medications, antiemetics, and decongestants. Two medications have been approved to treat ... The latest weight loss drugs work in a new way to help you shed pounds with minimal side effects. Learn how they do it and why you take them long term. ... (Qsymia®): This medication also ...Aug 4, 2022 · Other side effects. Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Serious eye problems which include: I have been on Qsymia since 2016, I lost 45 lbs and have kept it off since then. I weigh 163 and wish I could lose at least 8 more lbs, but I have plateaued. I have been taking it this long and had no side effects only at the first 2 weeks I had the tingling sensation on my legs.Objective: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. Methods: Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months). trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Serious eye problems which include:Mar 22, 2019 · An inexpensive weight-loss drug approved 60 years ago for only short-term use also may be safe and effective for longer-term treatment, according to a study conducted by researchers at Wake Forest ... Adults Adverse reactions occurring at greater than or equal to 5% and at least 1.5 times placebo in adults include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth. Adverse reactions reported in greater than or equal to 2% of QSYMIA-treated adults and more frequently than in the placebo group are shown in Table 3. Table 3.Phentermine acts much like a stimulant and has many of the same side effects: increased heart palpitations. increased blood pressure. dizziness. Phentermine is known for being one part of Fen-Phen ...Approved for long-term use? Yes. Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone. Side effects: The most common side effects are tingling hands ...Jun 28, 2023 · Extreme happiness or sadness. Symptoms of dangerously high blood pressure, such as severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, or seizures. These symptoms can indicate a serious phentermine side effect. Aug 17, 2019 · 1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ... Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough, runny ...Jun 28, 2023 · Extreme happiness or sadness. Symptoms of dangerously high blood pressure, such as severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, or seizures. These symptoms can indicate a serious phentermine side effect. Summary. Commonly reported side effects of orlistat include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules.Serious side effects vary by drug but can include depression, heart palpitations, fast or irregular heartbeat, increased blood pressure, dizziness, tremors, chest pain, and difficulty breathing ...Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...The latest weight loss drugs work in a new way to help you shed pounds with minimal side effects. Learn how they do it and why you take them long term. ... (Qsymia®): This medication also ...Feb 3, 2023 · Phentermine alone is designed for short-term use only, as there are few long-term studies on its safety. One study observed that people experienced no significant side effects when they took ... The table below lists prescription drugs approved by the FDA for weight loss. The FDA has approved five of these drugs—orlistat (Xenical, Alli), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), liraglutide (Saxenda), and semaglutide (Wegovy)—for long-term use. Jan 3, 2020 · The Bottom Line. Qsymia is a prescription-only weight loss medication that, when used in conjunction with diet and exercise, has a proven track record in overweight and obese individuals. The most common adverse effects are abnormal skin sensations, dizziness, altered taste, insomnia, constipation, and dry mouth, more severe issues can occur. 1. Nausea and vomiting. Nausea is the most common semaglutide side effect. Up to 20% of people taking it for Type 2 diabetes reported nausea in clinical trials. Nausea is even more common if you’re taking the higher-dose version for weight loss. Vomiting tends to be less common than nausea.Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Side effects include: Oily spotting ...This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment.Aug 17, 2019 · 1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ... 1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ...After stopping phentermine, some people experience feelings of weariness and fatigue due to the sudden lack of chemical stimulation. If you are tired after stopping phentermine, take care to: Get enough sleep. Fuel your body with healthy foods: avoid high-fat, high-carb, and high-sugar goods that may worsen fatigue. Stay lightly active.At 6 months, a year, and 2 years after starting phentermine, weight loss was clinically significantly greater among people who used the medication longer-term (more than a year) or medium-term (more than112 days but less than a year) than in people who used it for only 3 months.Mar 9, 2020 · However, the EMA has not approved this medication due to its abuse potential, the lack of long-term data on the cardiovascular effects of phentermine, and the cognitive side effects of topiramate—attention, language, and memory impairment . As this drug combination contains phentermine, it is a controlled DEA schedule IV substance. The combination of phentermine and extended-release topiramate (Qsymia) was approved by the FDA in July 2012 as an adjunct to a reduced-calorie diet and exercise for long-term weight management in individuals with an initial BMI of 30 kg/m 2 or higher (obese) or 27 kg/m 2 or higher (overweight) with at least one weight-related comorbid ...Jan 25, 2021 · These are the most common Topamax side effects, according to the manufacturer: Loss of appetite, changes in taste, weight loss, stomach pain, and even anorexia. GI side effects (nausea, diarrhea, indigestion) Tiredness. Paresthesia (tingling or prickling sensations) Speech problems. Cognitive dysfunction (trouble with memory and thinking) Upper ... The Saxenda Savings Card allows you to pay as little as a $25 copay or save up to $200 per Saxenda prescription. The Savings Card program allows for up to 12 benefits annually. There are eligibility requirements, and other restrictions apply. According to GoodRX, out-of-pocket prices range from $1332.59 to $1432.91.Qsymia may affect how you think and cause confusion, problems with concentration, attention, memory or speech. Tell your healthcare provider if symptoms occur. Slowing of growth. Qsymia may slow the increase in height in children 12 years and older. Increases of acid in bloodstream (metabolic acidosis). Aug 1, 2023 · These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about ... 1. Nausea and vomiting. Nausea is the most common semaglutide side effect. Up to 20% of people taking it for Type 2 diabetes reported nausea in clinical trials. Nausea is even more common if you’re taking the higher-dose version for weight loss. Vomiting tends to be less common than nausea.Other side effects. Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Objective: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. Methods: Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months).The SELECT trial is the long-term cardiovascular outcomes trial for Wegovy that aims to assess its effects on heart disease and stroke in patients with overweight and obesity; it is currently ongoing and expected to be completed in September 2023. Anti-obesity medication management: An evolving landscapeThe highest dose of Qsymia contains only 15mg of Phentermine, but the average dose of Phentermine (for weight loss when used by itself) is 37.5mg. While it may be nice to have a combination medication, it may actually be better to prescribe both medications individually so you have more control over the dosages of each medication.During the last few decades, some anti-obesity drugs were used to treat morbid obesity; however, many of them were removed from the market owing to long-term side effects, particularly cardiovascular issues . Since then, anti-obesity drug development process focusses on both weight loss efficacy and cardiovascular safety.Phentermine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phentermine belongs to the group of medicines known as appetite suppressants. This medicine is available only with your doctor's prescription.ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ Select Download Format Qsymia Long Term Side Effects Download Qsymia Long Term Side Effects PDF Download Qsymia Long Term Side Effects DOC ᅠ Bottle tightly closed when topiramate can think and pregnancy, food cravings to ensure that the sponsor. Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...Introduction. The worldwide prevalence of overweight and obesity, defined as having a body mass index (BMI) between 25.0–29.9 kg/m 2 and ≥30.0 kg/m 2, 1 has almost tripled since the 1970s, with nearly 40% of adults being overweight and 13% obese, and these numbers have been steadily increasing. 2 Patients with obesity are at an increased risk of developing comorbidities such as ...trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Serious eye problems which include: Jan 1, 2014 · Phentermine has the advantage of low cost and many years of clinical experience, but its long-term use is considered off-label, long-term effects on CVD outcomes are unknown, and most use has been a few months or less. 41 There are even fewer data for long-term safety and efficacy of the other noradrenergic agents. Orlistat has a reasonably ... This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment.Aug 3, 2023 · What Is Wegovy? Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e ... In clinical studies, patients lost the most weight after taking Contrave for 36 weeks and maintained weight loss through 56 weeks. In terms of phentermine weight loss, studies were only done for a short period of time. Once you stop phentermine, your appetite will return to normal. As a result, weight gain may occur.Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...Tardive dyskinesia is a movement disorder that is a side effect of medications, especially first-generation antipsychotics. Less common causes are second-generation antipsychotics, antidepressants, mood stabilizers, antiepileptic drugs, movement disorder medications, antiemetics, and decongestants. Two medications have been approved to treat ...1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ...Jul 18, 2021 · Paresthesia (tingling, numbness) of the extremities (15-38%) Dizziness (11-28%) Dysgeusia (abnormal taste sensation) (6-19%) Insomnia (7-17%) Constipation (6-16%) Dry mouth (5-14%) Headache (5-14%) Nausea (5-13%) Diarrhea (4-11%) Upper respiratory tract infection (4-9%) Oct 14, 2022 · In fact, this sort of weight loss is referred to as yo-yo dieting (yes, even if it comes secondary to the use of prescription medication) and can cause some serious long-term problems. #2. Using Phentermine Daily Can and Dose Cause Metabolic Damage. Perhaps the single biggest reason to avoid using Phentermine is that it can cause something ... This combination consists of fixed lower doses of phentermine and topiramate (3.75/23, 7/46, 11.25/69 and 15/92 mg) and is available in capsules under the brand name Qsymia. Common side effects of phentermine include nervousness, excitability, insomnia, headache, dry mouth, sweating, tachycardia, palpitations, nausea, constipation, and thirst.

However, the EMA has not approved this medication due to its abuse potential, the lack of long-term data on the cardiovascular effects of phentermine, and the cognitive side effects of topiramate—attention, language, and memory impairment . As this drug combination contains phentermine, it is a controlled DEA schedule IV substance.. Heimler

qsymia long term side effects

From research studies, an outline of the common and rare side effects associated with Qsymia is as follows: Common side effects (reported in more than 1% of patients): Paresthesia (tingling, numbness) of the extremities (15-38%) Dizziness (11-28%) Dysgeusia (abnormal taste sensation) (6-19%) Insomnia (7-17%) Constipation (6-16%)May 4, 2023 · How Long Will Phentermine Last. This drug’s side effects are mild, including fatigue, dizziness, headache, restlessness, nervousness, impotence, sleepiness, and nausea. Phentermine is generally prescribed by doctors and used for depression that is not responding to other treatments. The drug is also used as a weight-loss aid. Common Side Effects of Weight Loss Drugs. Increased blood pressure and heart rate, insomnia, nervousness, restlessness, dependence, abuse or withdrawal may occur with long-term use. When given as a single agent, phentermine is not implicated in valvular heart disease; avoid use at bedtime.Sep 21, 2018 · Using nonexposed periods in former users as a comparison achieves partial balance for obesity status. Second, because the signal of potential concern with Qsymia is increased heart rate—an effect that does not persist after the drug is withdrawn—the potential for carryover effects beyond current use was considered remote. Key variables Approved for long-term use? Yes. Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone. Side effects: The most common side effects are tingling hands ...Aug 3, 2023 · What Is Wegovy? Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e ... 1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ...Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...Qsymia may affect how you think and cause confusion, problems with concentration, attention, memory or speech. Tell your healthcare provider if symptoms occur. Slowing of growth. Qsymia may slow the increase in height in children 12 years and older. Increases of acid in bloodstream (metabolic acidosis). This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment.Apr 11, 2017 · Serious side effects vary by drug but can include depression, heart palpitations, fast or irregular heartbeat, increased blood pressure, dizziness, tremors, chest pain, and difficulty breathing ... Mar 29, 2022 · Tardive dyskinesia is a movement disorder that is a side effect of medications, especially first-generation antipsychotics. Less common causes are second-generation antipsychotics, antidepressants, mood stabilizers, antiepileptic drugs, movement disorder medications, antiemetics, and decongestants. Two medications have been approved to treat ... .

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